castleman disease การใช้

• Castleman disease ( CD ) is a lymphoproliferative disorder of unknown cause.
• Castleman disease is a focus of intense ongoing research.
• Castleman disease must be distinguished from other disorders that can demonstrate " Castleman-like " lymph node features, including reactive lymph node hyperplasia, autoimmune disorders, and malignancies.
• Human herpesvirus 8 ( HHV-8 ), also known as Kaposi sarcoma-associated herpesvirus ( KSHV ) has been found in some cases of multicentric Castleman disease ( MCD ).
• Multicentric Castleman disease ( MCD ) involves hyperactivation of the immune system, excessive release of proinflammatory chemicals ( cytokines ), proliferation of immune cells ( B cells and T cells ), and multiple organ system dysfunction.